It depends on your platform.
In Android, yes you can. However, I do not know if Unity handles the background running natively or if you need to make a plugin for the app.
In iOS, not really. While yes, there is limited multitasking (multi-apps-running-at-the-same-time) support for iOS, the general behavior is to exit the application when the home button is pressed.
I don't really have experience with this so you might need to do some digging and you might need to make some plugins.
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